Rubber cement (solvent-based adhesive) — household safety profile

What is this product?

Solvent-based rubber cement containing natural or synthetic rubber dissolved in n-hexane and/or heptane. Used in arts/crafts, paper mounting, and office applications. n-Hexane is neurotoxic — chronic exposure causes peripheral neuropathy (hexane neuropathy) through its metabolite 2,5-hexanedione, which crosslinks neurofilament proteins. Heptane is less neurotoxic but still a CNS depressant. Both solvents are highly flammable and have significant abuse potential as inhalants. Use in schools and by children/adolescents raises particular concern for both neurotoxicity and intentional inhalant abuse.

What's in it

Click any compound name for its full safety profile, regulatory consensus, and exposure data.

How to use it more safely

• Use only in well-ventilated areas
• Cap tightly immediately after use
• Use minimum amount needed
• Keep away from heat/flame/sparks

Red flags — when to walk away

• Contains n-hexane and used in enclosed space — Neurotoxic solvent exposure

Green flags — what to look for

• Heptane-only or water-based formula — Eliminates n-hexane neurotoxicity concern

Safer alternatives

• Glue stick (solid PVA adhesive) — Zero solvent exposure; safe for children; adequate for most paper bonding
• Heptane-based rubber cement — Heptane is less neurotoxic than n-hexane; still flammable but reduced neuropathy risk

Frequently asked questions