Home Safety / Products / Rodenticide Secondary Poisoning (Anticoagulant Brodifacoum — Dogs Eating Poisoned Mice, Vitamin K1 Treatment Protocol)

Rodenticide Secondary Poisoning (Anticoagulant Brodifacoum — Dogs Eating Poisoned Mice, Vitamin K1 Treatment Protocol) — household safety profile

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Secondary (relay) rodenticide poisoning is one of the most common canine toxicoses — dogs consume poisoned or dying rodents that contain lethal concentrations of anticoagulant rodenticides.

What is this product?

Secondary (relay) rodenticide poisoning is one of the most common canine toxicoses — dogs consume poisoned or dying rodents that contain lethal concentrations of anticoagulant rodenticides. Brodifacoum is the most potent second-generation anticoagulant rodenticide (SGAR) — a single feeding of a poisoned mouse or rat can deliver a lethal dose to a dog. Brodifacoum's oral LD50 in dogs is 0.25-3.6 mg/kg, and a single mouse carcass may contain 0.5-2.0 mg brodifacoum. A 20-kg dog consuming 2-3 poisoned mice could receive a lethal dose. ASPCA APCC: rodenticide is among the top 5 pet poisoning calls annually (~10,000 cases/year). Brodifacoum's biological half-life is 92-168 days in dogs (vs. 24-56 days for warfarin) — requiring extended vitamin K1 treatment for 4-6 weeks minimum, with monitoring for an additional 48-72 hours after discontinuation. Second-generation anticoagulants (brodifacoum, bromadiolone, difethialone, difenacoum) are lethal in a single dose — unlike first-generation warfarin which typically requires multiple feedings. EPA restricted consumer sale of SGARs in 2011 (bait station-only for outdoors), but professional-use and existing stock remain widely available. Bromethalin, a non-anticoagulant rodenticide increasingly used as a replacement, causes cerebral edema with no antidote — making it potentially more dangerous for exposed pets.

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Active Toxicant

Alternative Toxicant

First Generation Anticoagulant

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